Negative regulation of acute inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G2D, SPN, and CSF2RA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of acute inflammatory response to antigenic stimulus activity versus PLA2G2D in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLA2G2D →	+1.468	+0.873	<.001	<.001	3	8
OV	SPN →	+0.872	+0.674	<.001	<.001	3	8
GBM	CSF2RA →	+0.697	+0.598	.002	.005	3	8
CCRCC	CIITA →	+0.698	+0.591	<.001	<.001	3	8
LSCC	GVINP1 →	+1.027	+0.906	<.001	<.001	3	8
HNSC	CSF3R →	+1.191	+0.900	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002865 vs PLA2G2D — BRCA

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