Negative regulation of acute inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD83, SET, and LRRC8A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD83 grouped by Negative regulation of acute inflammatory response to antigenic stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CD83 →	-1.134	-0.984	.001	.002	3	5
STOMACH	SET →	-0.683	-1.296	.001	.006	3	5
PANCREAS	LRRC8A →	-1.187	-1.144	.008	.001	3	4
PANCREAS	PTAFR →	-2.749	-1.051	<.001	.001	3	4
URINARY_TRACT	CDC42BPG →	-2.945	-1.779	.003	.004	3	4
LUNG_NSCLC_LUSC	SFXN5 →	+0.706	+1.318	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD83 by Negative regulation of acute inflammatory response to antigenic stimulus activity — SKIN

Explore this box plot interactively →