Regulation of acute inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVG, SKAP2, and THEMIS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acute inflammatory response to antigenic stimulus activity versus PARVG in CCRCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PARVG →	+0.436	+0.080	<.001	<.001	3	8
GBM	SKAP2 →	+0.423	+0.066	.006	.001	3	7
BRCA	THEMIS2 →	+0.427	+0.047	<.001	<.001	3	7
COAD	TRPV2 →	+0.388	+0.063	<.001	<.001	3	7
LSCC	WDFY4 →	+0.444	+0.094	<.001	<.001	3	7
COAD	WIPF1 →	+0.363	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002864 vs PARVG — CCRCC

Explore this scatter interactively →