Regulation of acute inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM40, OCIAD2, and FHL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM40 grouped by Regulation of acute inflammatory response to antigenic stimulus-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEM40 →	-3.998	-1.402	<.001	.004	3	5
PANCREAS	OCIAD2 →	-1.134	-1.098	.002	.004	3	4
LUNG_NSCLC_LUSC	FHL2 →	-2.478	-1.176	.002	.004	3	4
SOFT_TISSUE	SAMD10 →	-1.218	-1.559	.001	.001	3	4
SOFT_TISSUE	RYK →	-0.589	-0.990	<.001	.005	3	4
OVARY	HADH →	+0.655	+1.164	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM40 by Regulation of acute inflammatory response to antigenic stimulus activity — URINARY_TRACT

Explore this box plot interactively →