Regulation of acute inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of acute inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF157, SCLY, and SPATA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acute inflammatory response to antigenic stimulus activity versus RNF157 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RNF157 →	+1.187	+0.173	.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	SCLY →	+0.614	+0.181	.003	<.001	3	5
STOMACH	SPATA6 →	+1.716	+0.451	<.001	.001	3	5
BREAST	RAB3A →	+1.148	+0.209	.004	.004	3	4
OVARY	RTP4 →	-1.613	-0.218	.001	.008	3	4
OESOPHAGUS	RSAD1 →	+0.944	+0.179	.006	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002864 vs RNF157 — LUNG_NSCLC_LUAD

Explore this scatter interactively →