Positive regulation of inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBB, ADAP2, and FPR3, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response to antigenic stimulus activity versus CYBB in CHOL (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CYBB →	-2.944	-0.159	<.001	<.001	3	26
UVM	ADAP2 →	-1.389	-0.094	<.001	<.001	3	26
BLCA	FPR3 →	-1.504	-0.064	<.001	<.001	3	26
CHOL	CD4 →	-2.399	-0.164	<.001	<.001	3	25
CHOL	MS4A6A →	-2.202	-0.144	<.001	<.001	3	25
CHOL	PLEK →	-3.013	-0.177	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002863 vs CYBB — CHOL

Explore this scatter interactively →