Positive regulation of inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, GZMK, and SLA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response to antigenic stimulus activity versus TLR8 in HNSC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TLR8 →	+0.930	+0.157	.001	<.001	3	5
HNSC	GZMK →	+0.874	+0.110	.001	.003	3	5
HNSC	SLA2 →	+0.596	+0.107	.001	<.001	3	4
HNSC	TNFSF13B →	+1.050	+0.173	<.001	<.001	3	4
BRCA	IL15RA →	+0.761	+0.136	<.001	<.001	3	4
CCRCC	RABGAP1 →	-0.392	-0.219	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002863 vs TLR8 — HNSC

Explore this scatter interactively →