Positive regulation of inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG8, COMMD10, and SDHB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response to antigenic stimulus activity versus COG8 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	COG8 →	+0.611	+0.197	.007	.002	2	7
SOFT_TISSUE	COMMD10 →	-0.737	-0.230	.002	.001	3	5
LUNG_NSCLC_LUAD	SDHB →	+0.598	+0.267	<.001	<.001	3	5
BONE	POLR1B →	+0.941	+0.315	.004	<.001	3	5
STOMACH	DHODH →	+0.922	+0.307	<.001	.002	3	5
BONE	DDX28 →	+0.823	+0.329	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002863 vs COG8 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →