Positive regulation of inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KARS1, AARS1, and NUTF2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response to antigenic stimulus activity versus KARS1 in STOMACH (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KARS1 →	+0.967	+0.293	<.001	<.001	3	16
LARGE_INTESTINE	AARS1 →	+1.929	+0.295	<.001	<.001	3	16
PANCREAS	NUTF2 →	+2.528	+0.273	<.001	<.001	3	16
PANCREAS	USP10 →	+1.062	+0.160	<.001	.002	3	16
PANCREAS	FARSB →	+1.741	+0.255	.001	<.001	3	15
PANCREAS	IARS1 →	+0.967	+0.167	.001	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002863 vs KARS1 — STOMACH

Explore this scatter interactively →