Negative regulation of inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, RIN3, and SPN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response to antigenic stimulus activity versus LCP2 in BRCA (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LCP2 →	+0.462	+0.052	<.001	<.001	3	10
GBM	RIN3 →	+0.384	+0.061	<.001	<.001	3	9
OV	SPN →	+0.755	+0.052	.002	.001	3	9
BRCA	RCSD1 →	+0.573	+0.065	<.001	<.001	3	9
GBM	DEF6 →	+0.548	+0.065	<.001	<.001	3	9
BRCA	DPYD →	+0.461	+0.050	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002862 vs LCP2 — BRCA

Explore this scatter interactively →