Negative regulation of inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND5A, IQANK1, and TMEM265, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response to antigenic stimulus activity versus DENND5A in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DENND5A →	+3.716	+0.256	.001	<.001	3	5
STOMACH	IQANK1 →	-3.548	-0.229	<.001	<.001	3	5
STOMACH	TMEM265 →	-2.995	-0.170	<.001	.002	3	5
PANCREAS	NFIC →	+1.511	+0.358	.003	.004	3	5
SOFT_TISSUE	IRF2BPL →	+1.528	+0.321	<.001	.006	3	4
BLOOD_Leukemia	TIMM23 →	-0.552	-0.169	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002862 vs DENND5A — STOMACH

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