Regulation of inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDF2, AANAT, and NOD2, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammatory response to antigenic stimulus activity versus RHBDF2 in LGG (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RHBDF2 →	+1.188	+0.058	<.001	<.001	3	22
LAML	AANAT →	+0.620	+0.036	<.001	<.001	3	20
LAML	NOD2 →	+1.422	+0.049	<.001	<.001	3	18
LGG	TREML1 →	+0.939	+0.048	<.001	<.001	3	18
PAAD	LYL1 →	+0.870	+0.032	<.001	<.001	3	17
LGG	ABI3 →	+1.014	+0.047	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002861 vs RHBDF2 — LGG

Explore this scatter interactively →