Regulation of inflammatory response to antigenic stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, LCP1, and RGS19, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammatory response to antigenic stimulus activity versus STK10 in LSCC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STK10 →	+0.375	+0.067	<.001	<.001	3	9
GBM	LCP1 →	+0.883	+0.082	<.001	<.001	3	8
PDAC	RGS19 →	+0.493	+0.042	<.001	<.001	3	8
BRCA	SASH3_S97 →	+0.734	+0.048	<.001	<.001	3	8
OV	SPN →	+0.674	+0.037	.005	.003	2	9
GBM	TBC1D2B →	+0.356	+0.081	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002861 vs STK10 — LSCC

Explore this scatter interactively →