Regulation of inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQANK1, CCDC88A, and STARD10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammatory response to antigenic stimulus activity versus IQANK1 in URINARY_TRACT (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IQANK1 →	-3.724	-0.464	.009	.003	2	7
OESOPHAGUS	CCDC88A →	+1.721	+0.314	.009	.002	3	6
LUNG_NSCLC_LUAD	STARD10 →	-1.538	-0.179	.001	<.001	3	6
LUNG_NSCLC_LUAD	CAMSAP3 →	-1.128	-0.175	.006	.004	3	6
URINARY_TRACT	CRB3 →	-3.562	-0.546	.005	.003	3	5
PANCREAS	PTAFR →	-2.224	-0.299	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002861 vs IQANK1 — URINARY_TRACT

Explore this scatter interactively →