Positive regulation of natural killer cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Positive regulation of natural killer cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL131P, KSR2, and KRASP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell mediated immune response to tumor cell activity versus RN7SL131P in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL131P →	+0.154	+0.643	.009	.001	3	3
UCEC	KSR2 →	-0.594	-0.599	.003	.006	3	3
BRCA	KRASP1 →	+0.125	+0.712	<.001	<.001	3	2
BRCA	TAPBP →	-0.629	-0.798	.001	<.001	3	2
BRCA	MIR4717 →	-0.240	-0.733	.005	.006	3	2
LUAD	SBDS →	-0.233	-0.580	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002857 vs RN7SL131P — LUAD

Explore this scatter interactively →