Positive regulation of natural killer cell mediated immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPPK, KLHDC9, and BRF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IPPK grouped by Positive regulation of natural killer cell mediated immune response to tumor cell-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IPPK →	+0.486	+1.030	<.001	<.001	3	4
STOMACH	KLHDC9 →	-2.506	-1.483	<.001	<.001	3	3
LUNG_NSCLC_LUAD	BRF1 →	-0.675	-0.837	.001	.009	3	3
LUNG_SCLC	GFM2 →	+0.464	+1.026	.001	<.001	3	3
PANCREAS	ZNF684 →	+0.664	+1.266	.002	.001	3	3
LIVER	PEMT →	+1.330	+1.675	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IPPK by Positive regulation of natural killer cell mediated immune response to tumor cell activity — SKIN

Explore this box plot interactively →