Regulation of natural killer cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell mediated immune response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TES_S168, PTPRE, and TGFB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell mediated immune response to tumor cell activity versus TES_S168 in PDAC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TES_S168 →	+0.347	+0.066	<.001	.002	3	6
BRCA	PTPRE →	+0.370	+0.046	<.001	.002	3	6
GBM	TGFB1 →	+0.428	+0.075	<.001	<.001	3	6
LUAD	PLAUR →	+0.326	+0.044	.002	.003	3	6
LUAD	NFIA →	-0.231	-0.056	.002	<.001	3	6
LUAD	IL1RAP_S557 →	+0.903	+0.058	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002855 vs TES_S168 — PDAC

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