Regulation of natural killer cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR6851, IQSEC3, and BPIFC, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell mediated immune response to tumor cell activity versus MIR6851 in UCEC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6851 →	-0.857	-0.721	<.001	<.001	3	3
BRCA	IQSEC3 →	-0.351	-0.528	<.001	.001	3	2
BRCA	BPIFC →	+0.043	+0.448	.002	.003	3	2
BRCA	LINC02400 →	-0.022	-0.591	.001	.008	3	2
BRCA	PRSS58 →	-0.045	-0.691	.008	.002	3	2
CCRCC	STX19 →	-0.369	-0.422	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002855 vs MIR6851 — UCEC

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