Positive regulation of response to tumor cell

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLK, YLPM1, and KANSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLK grouped by Positive regulation of response to tumor cell-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NLK →	-0.805	-0.295	.008	.005	3	4
LUNG_SCLC	YLPM1 →	-0.726	-0.317	.004	<.001	3	3
LUNG_SCLC	KANSL1 →	-0.870	-0.270	<.001	<.001	3	3
LUNG_SCLC	GZF1 →	-0.533	-0.249	.003	.001	3	3
LUNG_SCLC	CEP350 →	-0.636	-0.289	.005	.001	3	3
LUNG_SCLC	AGER →	-1.226	-0.345	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLK by Positive regulation of response to tumor cell activity — LUNG_SCLC

Explore this box plot interactively →