Positive regulation of response to tumor cell

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PVR, NECTIN2, and PHLDB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to tumor cell activity versus PVR in BONE (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PVR →	+1.592	+0.372	.001	<.001	3	7
BONE	NECTIN2 →	+1.915	+0.363	.005	.001	3	7
STOMACH	PHLDB2 →	+3.208	+0.228	<.001	<.001	3	7
BREAST	NUB1 →	+0.658	+0.165	.001	<.001	3	6
STOMACH	THBS1 →	+4.738	+0.273	<.001	.001	3	6
BREAST	ZEB1 →	+1.626	+0.207	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002836 vs PVR — BONE

Explore this scatter interactively →