Regulation of response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD3, SAMSN1, and SKAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to tumor cell activity versus AMPD3 in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AMPD3 →	+0.619	+0.097	<.001	<.001	3	10
GBM	SAMSN1 →	+0.555	+0.066	<.001	<.001	3	9
GBM	SKAP2 →	+0.736	+0.094	<.001	<.001	3	9
UCEC	THEMIS2_T593 →	+0.727	+0.077	.004	<.001	3	9
GBM	TNFAIP8L2 →	+0.641	+0.072	<.001	<.001	3	9
GBM	DEF6 →	+0.660	+0.091	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002834 vs AMPD3 — GBM

Explore this scatter interactively →