Regulation of response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1GALT1P3, NR1H3, and IL2RB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to tumor cell activity versus C1GALT1P3 in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1GALT1P3 →	+0.332	+0.133	.003	.001	3	4
LSCC	NR1H3 →	+0.397	+0.148	<.001	<.001	3	4
LSCC	IL2RB →	+0.933	+0.185	<.001	<.001	3	3
LSCC	DOCK8 →	+0.923	+0.205	<.001	<.001	3	3
LSCC	CD72 →	+0.765	+0.176	<.001	<.001	3	3
LSCC	SIGLEC10 →	+0.911	+0.162	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002834 vs C1GALT1P3 — LSCC

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