Regulation of response to tumor cell

Across TCGA cell cohorts, RNA activity of the Regulation of response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP1, CAPNS1, and TNFRSF1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to tumor cell activity versus VAMP1 in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	VAMP1 →	+1.168	+0.195	.008	.003	3	5
BREAST	CAPNS1 →	+0.671	+0.186	.008	.002	3	5
LUNG_NSCLC_LUSC	TNFRSF1A →	+2.143	+0.231	.003	.003	2	6
LIVER	SH3TC1 →	+3.378	+0.263	<.001	<.001	3	5
BREAST	SEC23A →	+1.023	+0.165	.001	.006	2	5
BREAST	ARL2BP →	+0.935	+0.184	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002834 vs VAMP1 — PANCREAS

Explore this scatter interactively →