Negative regulation of response to biotic stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to biotic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK2, AIF1, and IFIT2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to biotic stimulus activity versus CMPK2 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CMPK2 →	+0.608	+0.055	<.001	<.001	3	10
GBM	AIF1 →	+0.833	+0.053	<.001	<.001	3	10
LSCC	IFIT2 →	+0.758	+0.052	<.001	<.001	3	10
LSCC	IFIT3 →	+0.920	+0.055	<.001	<.001	3	10
UCEC	DOCK10 →	+0.426	+0.050	<.001	.001	3	9
GBM	DTX3L →	+0.443	+0.031	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002832 vs CMPK2 — LSCC

Explore this scatter interactively →