Negative regulation of response to biotic stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCHF9, CCDC40, and SASH3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to biotic stimulus activity versus MARCHF9 in LIVER (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MARCHF9 →	-1.715	-0.214	.001	<.001	3	4
LIVER	CCDC40 →	-1.138	-0.184	.008	.005	3	4
PANCREAS	SASH3 →	-0.142	-0.164	.005	.007	3	4
PANCREAS	SLC46A1 →	-0.817	-0.206	<.001	.001	3	4
STOMACH	ATP5F1D →	-0.852	-0.209	.005	.006	3	4
SKIN	DLX6 →	-0.804	-0.155	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002832 vs MARCHF9 — LIVER

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