Positive regulation of type 2 immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAMF1, ICOS, and IKZF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type 2 immune response activity versus SLAMF1 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLAMF1 →	+0.673	+0.468	<.001	.003	3	6
LSCC	ICOS →	+0.627	+0.814	.001	<.001	3	6
LSCC	IKZF1 →	+0.698	+0.760	<.001	<.001	3	6
HNSC	TIFAB →	+0.597	+0.636	<.001	<.001	3	6
LSCC	P2RY10 →	+0.650	+0.684	<.001	<.001	3	6
LSCC	SP140 →	+0.636	+0.629	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002830 vs SLAMF1 — HNSC

Explore this scatter interactively →