Positive regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of type 2 immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XCL1, GATA3, and ARSJ, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XCL1 grouped by Positive regulation of type 2 immune response-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	XCL1 →	-0.306	-1.273	.001	<.001	3	9
BREAST	GATA3 →	-0.481	-1.244	<.001	<.001	3	6
PANCREAS	ARSJ →	-0.215	-1.346	.008	.002	3	5
LUNG_SCLC	PHF5A →	-0.546	-1.295	.001	.002	3	4
BLOOD_Myeloma	ATR →	+0.477	+1.394	.001	.009	3	4
CNS	HOXB6 →	-0.247	-1.406	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XCL1 by Positive regulation of type 2 immune response activity — BLOOD_Leukemia

Explore this box plot interactively →