Positive regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOAP1, ZNF2, and CFB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOAP1 grouped by Positive regulation of type 2 immune response-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MOAP1 →	+0.755	+0.768	.001	.005	3	4
CNS	ZNF2 →	+0.317	+0.893	<.001	.005	3	4
BREAST	CFB →	-2.206	-0.752	.002	.002	3	4
URINARY_TRACT	COL12A1 →	-4.496	-1.668	.002	<.001	3	4
STOMACH	LRRC1 →	-1.067	-0.767	.005	.009	3	4
SKIN	FGF5 →	-1.197	-0.728	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOAP1 by Positive regulation of type 2 immune response activity — KIDNEY

Explore this box plot interactively →