Positive regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD74, DHX35, and HLA-DRB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type 2 immune response activity versus CD74 in BLOOD_Leukemia (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD74 →	+5.035	+0.180	<.001	<.001	3	10
PANCREAS	DHX35 →	-0.775	-0.179	.002	.003	3	8
SKIN	HLA-DRB1 →	+4.120	+0.175	<.001	<.001	3	8
BLOOD_Leukemia	HLA-DRA →	+5.278	+0.184	<.001	<.001	3	8
LIVER	XPO4 →	-0.852	-0.143	.003	.002	3	7
OVARY	CENPJ →	-0.817	-0.154	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002830 vs CD74 — BLOOD_Leukemia

Explore this scatter interactively →