Positive regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD248, AMZ1, and GPR158, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type 2 immune response activity versus CD248 in PANCREAS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CD248 →	+0.195	+1.917	.008	.008	3	3
PANCREAS	AMZ1 →	+0.823	+1.850	.003	<.001	3	3
PANCREAS	GPR158 →	+1.816	+1.850	<.001	<.001	3	2
BLOOD_Lymphoma	ABI3BP →	+0.620	+0.275	.006	.005	3	2
LARGE_INTESTINE	ABCA3 →	+2.543	+1.212	.003	.004	3	2
LARGE_INTESTINE	SLC35G2 →	+1.661	+1.196	.007	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002830 vs CD248 — PANCREAS

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