Regulation of type 2 immune response

Across TCGA patient cohorts, RNA activity of the Regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCK, SIRPB2, and HTRA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type 2 immune response activity versus HCK in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCK →	+1.057	+0.960	<.001	<.001	3	6
OV	SIRPB2 →	+0.662	+0.963	.002	<.001	3	6
COAD	HTRA4 →	+0.507	+0.104	.005	.003	3	6
UCEC	SERPINB8 →	+0.790	+0.647	<.001	<.001	3	5
GBM	IL18RAP →	+1.001	+0.844	<.001	<.001	3	5
GBM	CR1 →	+0.932	+0.623	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002828 vs HCK — GBM

Explore this scatter interactively →