Regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT80, MAP1B, and DCBLD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRT80 grouped by Regulation of type 2 immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRT80 →	-2.142	-0.542	.001	.006	3	4
SKIN	MAP1B →	-2.131	-0.873	<.001	.007	3	4
SKIN	DCBLD2 →	-0.812	-0.824	.002	<.001	2	5
OVARY	IL4I1 →	-1.998	-0.952	.002	.001	3	4
CNS	ZDHHC12 →	-1.020	-0.805	.002	.002	2	4
OVARY	CTSS →	-2.666	-1.041	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRT80 by Regulation of type 2 immune response activity — CNS

Explore this box plot interactively →