Regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, CCN2, and CHST7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type 2 immune response activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+7.372	+1.736	<.001	.008	3	6
LUNG_NSCLC_LUSC	CCN2 →	+5.047	+0.437	<.001	.005	3	5
LUNG_NSCLC_LUSC	CHST7 →	+2.998	+0.325	<.001	.003	3	4
BLOOD_Myeloma	RTTN →	+1.353	+2.186	.006	.001	3	4
SOFT_TISSUE	STX11 →	+1.545	+1.801	.008	.007	2	5
LARGE_INTESTINE	EVA1C →	+1.628	+1.245	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002828 vs ANXA1 — SOFT_TISSUE

Explore this scatter interactively →