Positive regulation of T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDR2L, STK19, and NELFE, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 1 type immune response activity versus CDR2L in LUNG_NSCLC_LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CDR2L →	+1.199	+0.363	.004	.009	3	2
LUNG_NSCLC_LUAD	STK19 →	-0.617	-0.343	.004	.005	3	2
OESOPHAGUS	NELFE →	-0.746	-1.957	<.001	.002	3	2
BLOOD_Leukemia	AKT1S1 →	-0.980	-1.864	.001	<.001	3	2
LUNG_NSCLC_LUAD	TMEM205 →	+1.027	+0.532	.001	.002	3	1
LUNG_NSCLC_LUAD	SLC26A8 →	-0.092	-0.576	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002827 vs CDR2L — LUNG_NSCLC_LUAD

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