Negative regulation of T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 1 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, WIPF1, and CD4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 1 type immune response activity versus WAS in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.676	+0.132	<.001	<.001	3	9
OV	WIPF1 →	+0.447	+0.064	.004	<.001	3	9
GBM	CD4 →	+0.735	+0.113	<.001	<.001	3	9
GBM	DOCK2 →	+0.675	+0.132	<.001	<.001	3	9
GBM	GPSM3 →	+0.623	+0.131	<.001	<.001	3	9
GBM	AMPD3 →	+0.636	+0.106	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002826 vs WAS — GBM

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