Negative regulation of T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, SYNE3, and IL10RA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 1 type immune response activity versus PPP1R16B in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R16B →	+0.968	+0.227	<.001	.003	3	6
BRCA	SYNE3 →	+0.766	+0.270	<.001	.001	3	5
HNSC	IL10RA →	+1.004	+0.304	<.001	<.001	3	5
HNSC	CD226 →	+0.728	+0.274	<.001	.007	3	5
HNSC	FLI1 →	+0.742	+0.382	<.001	<.001	3	5
BRCA	IKZF3 →	+0.923	+0.159	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002826 vs PPP1R16B — HNSC

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