Negative regulation of T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM118B, SUPT20H, and TNFSF18, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 1 type immune response activity versus FAM118B in PANCREAS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FAM118B →	+1.031	+1.833	<.001	<.001	3	3
PANCREAS	SUPT20H →	+0.590	+1.833	.003	<.001	3	2
PANCREAS	TNFSF18 →	-1.569	-1.941	<.001	<.001	3	2
PANCREAS	GJA3 →	+1.338	+1.833	.005	<.001	3	2
PANCREAS	NUP210 →	+1.463	+1.833	.001	<.001	3	2
PANCREAS	THAP12 →	+1.220	+1.833	.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002826 vs FAM118B — PANCREAS

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