Regulation of T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 1 type immune response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and SAMSN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 1 type immune response activity versus RCSD1 in OV (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.714	+0.044	<.001	<.001	3	10
BRCA	RCSD1_S351 →	+0.779	+0.067	<.001	<.001	3	10
GBM	SAMSN1 →	+0.656	+0.089	<.001	<.001	3	10
GBM	SAMSN1_S107 →	+0.834	+0.106	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.889	+0.097	<.001	<.001	3	10
GBM	SASH3 →	+0.535	+0.095	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002825 vs RCSD1 — OV

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