Regulation of T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, FAM234B, and IFNG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 1 type immune response activity versus PLA2G4A in COAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.695	+0.970	<.001	<.001	3	7
BRCA	FAM234B →	-1.257	-0.493	<.001	.001	3	6
LSCC	IFNG →	+0.994	+0.436	<.001	.002	3	5
LSCC	PIK3R5 →	+0.778	+0.482	<.001	.001	3	5
LSCC	CCR5 →	+1.026	+0.577	<.001	<.001	3	5
LSCC	LAIR2 →	+0.310	+0.386	.004	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002825 vs PLA2G4A — COAD

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