Regulation of T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS2, MPZL3, and GADD45A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 1 type immune response activity versus TMPRSS2 in LARGE_INTESTINE (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMPRSS2 →	-3.086	-0.280	<.001	.001	3	5
LUNG_NSCLC_LUAD	MPZL3 →	-1.396	-0.199	.003	.008	3	4
BREAST	GADD45A →	+1.465	+0.764	.002	.001	3	4
BREAST	FAM126A →	+2.506	+1.011	<.001	.003	3	4
BREAST	PSMB2 →	+1.220	+1.104	<.001	<.001	3	4
BREAST	ANXA1 →	+3.380	+0.760	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002825 vs TMPRSS2 — LARGE_INTESTINE

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