Negative regulation of adaptive immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of adaptive immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN1, RAB41, and ALOXE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN1 grouped by Negative regulation of adaptive immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTPN1 →	+0.225	+0.979	<.001	<.001	3	5
URINARY_TRACT	RAB41 →	-0.255	-1.627	.003	<.001	3	4
LUNG_NSCLC_LUAD	ALOXE3 →	-0.115	-0.538	.004	.008	3	4
SKIN	HRH4 →	-0.130	-0.765	.008	.004	3	4
LIVER	CACNA1C →	-0.265	-0.971	.004	.006	2	5
SOFT_TISSUE	IFNB1 →	-0.380	-1.137	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN1 by Negative regulation of adaptive immune response activity — CNS

Explore this box plot interactively →