Negative regulation of adaptive immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of adaptive immune response pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN1, PRR5, and FAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SESN1 grouped by Negative regulation of adaptive immune response-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SESN1 →	+1.523	+1.677	.001	<.001	2	6
URINARY_TRACT	PRR5 →	+3.023	+1.677	<.001	<.001	3	4
STOMACH	FAS →	+2.083	+1.071	<.001	.007	2	5
KIDNEY	DDB2 →	+1.302	+1.655	.006	<.001	3	4
PANCREAS	ZDHHC7 →	+0.641	+0.960	.002	.001	3	4
STOMACH	BMF →	-2.612	-1.374	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SESN1 by Negative regulation of adaptive immune response activity — URINARY_TRACT

Explore this box plot interactively →