Negative regulation of adaptive immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of adaptive immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are N4BP2, DIPK1B, and TMEFF1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adaptive immune response activity versus N4BP2 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	N4BP2 →	-0.963	-0.076	<.001	<.001	3	13
OESOPHAGUS	DIPK1B →	-2.320	-0.086	<.001	<.001	3	13
BONE	TMEFF1 →	-1.388	-0.089	<.001	.002	3	13
STOMACH	ZNF286B →	-1.531	-0.112	<.001	<.001	3	13
STOMACH	TNFRSF14 →	+2.851	+0.110	<.001	<.001	3	13
LUNG_SCLC	NUP133 →	-0.637	-0.058	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002820 vs N4BP2 — LUNG_SCLC

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