Positive regulation of peptide secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of peptide secretion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCB1, RACGAP1, and MCM6_S762, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptide secretion activity versus PLCB1 in UCEC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLCB1 →	+0.580	+0.030	.002	.003	3	6
PDAC	RACGAP1 →	-0.510	-0.033	<.001	.005	3	6
BRCA	MCM6_S762 →	-0.800	-0.021	<.001	<.001	3	6
UCEC	TK2 →	+0.258	+0.028	.003	.001	2	6
LSCC	BAZ1B_S349 →	-0.843	-0.024	.003	.002	2	6
BRCA	UBA1_S835 →	-0.826	-0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002793 vs PLCB1 — UCEC

Explore this scatter interactively →