Positive regulation of peptide secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptide secretion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, GALNT6, and IFITM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC25A grouped by Positive regulation of peptide secretion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CDC25A →	-0.962	-0.169	.003	<.001	3	3
LUNG_NSCLC_LUAD	GALNT6 →	-1.989	-0.130	.002	.004	3	3
LUNG_NSCLC_LUAD	IFITM1 →	-1.569	-0.108	.006	.007	3	3
LUNG_NSCLC_LUAD	G2E3 →	-0.503	-0.133	.003	<.001	3	3
LUNG_SCLC	STIL →	+0.641	+0.183	.009	.003	3	3
LARGE_INTESTINE	VAC14 →	+0.482	+0.222	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC25A by Positive regulation of peptide secretion activity — PANCREAS

Explore this box plot interactively →