Positive regulation of peptide secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptide secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3A1, MATN3, and ATP1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptide secretion activity versus SF3A1 in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SF3A1 →	+0.595	+0.208	.009	.002	3	5
UPPER_AERODIGESTIVE_TRACT	MATN3 →	+1.451	+0.201	.001	.001	3	5
LIVER	ATP1B1 →	+2.182	+0.375	.009	.001	3	5
BLOOD_Leukemia	CEBPA →	-2.972	-0.193	<.001	<.001	3	5
BONE	ACSL4 →	+1.459	+0.309	.006	.003	3	4
BLOOD_Lymphoma	OGDH →	+0.718	+0.153	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002793 vs SF3A1 — BLOOD_Leukemia

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