Negative regulation of peptide secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptide secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYTL4, ZFYVE21, and ESD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptide secretion activity versus SYTL4 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SYTL4 →	+0.511	+0.025	.002	<.001	3	6
UCEC	ZFYVE21 →	+0.358	+0.052	<.001	.001	3	5
OV	ESD →	+0.603	+0.041	<.001	.001	3	5
BRCA	TLN2 →	+0.521	+0.029	<.001	<.001	3	5
UCEC	CNRIP1 →	+0.748	+0.047	<.001	.003	3	5
LSCC	IRS1 →	+0.501	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002792 vs SYTL4 — BRCA

Explore this scatter interactively →