Negative regulation of peptide secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptide secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN9, FOXO4, and C3orf18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptide secretion activity versus CAPN9 in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAPN9 →	+1.177	+0.645	.001	.001	3	5
BRCA	FOXO4 →	+0.761	+0.545	<.001	.003	3	5
BRCA	C3orf18 →	+0.823	+0.560	<.001	<.001	3	5
PDAC	G6PC2 →	+1.006	+0.258	.001	.002	3	5
LSCC	BCAS1 →	+0.893	+0.710	.001	<.001	3	5
LUAD	FOXS1 →	+0.378	+0.543	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002792 vs CAPN9 — BRCA

Explore this scatter interactively →