Negative regulation of peptide secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptide secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC7, LCN6, and ACVR2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC7 grouped by Negative regulation of peptide secretion-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNAJC7 →	-0.203	-1.126	.002	.008	3	6
BONE	LCN6 →	-0.349	-1.175	<.001	.005	3	4
SOFT_TISSUE	ACVR2B →	-0.208	-1.087	.008	.004	2	5
SOFT_TISSUE	COL6A3 →	-0.585	-1.358	<.001	.006	3	4
BLOOD_Myeloma	TLX1 →	-0.385	-1.857	<.001	<.001	3	4
BLOOD_Myeloma	CABP1 →	-0.215	-1.241	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC7 by Negative regulation of peptide secretion activity — BONE

Explore this box plot interactively →