Negative regulation of peptide secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptide secretion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCBLD1, PLEKHJ1, and TPGS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptide secretion activity versus DCBLD1 in BONE (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DCBLD1 →	-3.082	-0.748	.006	.005	3	6
STOMACH	PLEKHJ1 →	+0.692	+0.361	.008	<.001	3	5
BONE	TPGS1 →	+1.091	+0.663	.001	<.001	3	5
LUNG_SCLC	TIFA →	+1.105	+0.391	.002	.002	3	5
LUNG_SCLC	ZFP69B →	+1.328	+0.334	.006	.002	3	5
BONE	LUC7L →	+0.864	+0.508	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002792 vs DCBLD1 — BONE

Explore this scatter interactively →